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What does it mean when they say that Kawasaki Disease may be an Autoimmune Disorder, or an Autoimmune Disease?

There has been much contraversy in the past regarding Kawasaki Disease and "Autoimmune".  Here is some information that will perhaps help you to decide.  Is Kawasaki Disease an Autoimmune Disease? 

THAT'S ME...In the hospital in February 1994

What is Autoimmunity?

One of the functions of the immune system is to protect the body from invasions of viruses and bacteria.  In normal cases, this is precisely what happens.  However, in some cases, the immune system makes a mistake and attacks healthy cells in tissue and organs instead of the invader.  This is known as an autoimmune response.  Many research documents indicate that Kawasaki Disease "may" be an autoimmune reponse to a "possible" toxin or bacteria that has entered the body.   There has also been much documentation regarding the "genetic predisposition" of a Kawasaki patient that makes him/her more succeptible to an autoimmune response.  To conclude that Kawasaki Disease is in fact an Autoimmune Disease, may be stretching it...However, research points to the strong possibility that is is indeed somehow related to autoimmunity. 

NOPE...sorry those aren't my feet...but thanks to a friend in TN, these are the feet of a Kawasaki Kid

There are two main types of Autoimmunity;  Organ-Specific and Non-Organ Specific: 

Organ Specific is when the autoimmunity is directed at a specific organ.  This is apparent in diabetes(pancreas), Addison's disease(adrenal glands) and thyroiditis( the thyroid) as well as many others.

Non-Organ Specific is when the autoimmunity is widespread throughout the body.  This is apparent in illnesses such as Lupus, Rheumatoid Arthritis, and others.


 

Please Visit the Autoimmune Association Website for more information on specific Autoimmune Disorders at www.aarda.org

 

Most Patients with Kawasaki Disease are treated with IVIG - Intravenous Gamma Globulin

What is IVIG?  IVIG is a solution of globulins containing antibodies normally present in adult human blood. Globulins are simple proteins that provide immunity against disease. A protein is made up of several amino acids, which are the microscopic building blocks that make up all cells. Many globulins are inherited, so that the body is able from birth to fight off bacteria and other infections. IVIG is used for treatment of people who are unable to produce sufficient amounts of immune globulin antibodies.

Food For Thought...
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Most Autoimmune diseases have an "unknown etiology"...meaning they don't know what causes it!

The autoimmune theory is still just a THEORY!  While there are several theories about the cause of KD, the cause still hasn't been pinned down. Many parents believe there is some truth to this theory, and many parents support other theories, such as the carpet cleaning connection.  In the end, we hope that parents, and patients of KD,  can somehow help researchers discover the true cause of KD by supplying answers to poll questions, submitting to DNA testing, and other requests that may help.

 
   
 

May God Be With You